Impact of PTMs on fibrin clot properties (IMAGE)
Caption
The top panel, designed with BioRender.com, illustrates the process of clot formation and lysis, beginning with platelet aggregation and activation of the coagulation cascade, followed by the conversion of fibrinogen to fibrin, and concluding with clot degradation into fibrin fragments. The middle panel emphasizes the influence of pro-thrombotic post-translational modifications (PTMs) on the fibrinogen molecule, showcasing various modifications (Ox: Oxidation, N: Nitration, P: Phosphorylation, G: Glycation, Gu: Guanidinylation, Ca: Carbamylation, H: Homocysteinylation, S: Sulfation, Ac: Acetylation, and M: Methylation) that alter its structural properties. The bottom panel highlights the effects of PTMs on clot formation dynamics, such as changes in lag phase, maximum absorbance, and velocity. Additionally, it depicts how PTMs induce structural alterations in clots, including thinner fibrin fibers, increased clot density, and reduced permeability, ultimately impacting clot susceptibility to fibrinolysis and contributing to thrombosis complications.
Credit
Matteo Becatti, Molecular Biomedicine, Springer Nature
Usage Restrictions
Free for distribution with proper credit.
License
Original content